Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

Abstract The innate immune system utilizes many approaches for defense against invading microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil extracellular traps (NETs) and release of antimicrobial peptides (AMPs). While classically thought to be driven by adaptive immunity, the development […]

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iRGD is a tumor penetrating peptide to fight cancer

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Author information Vascular Mapping Laboratory, Center for Nanomedicine, Sanford-Burnham Medical Research Institute at University of California at Santa Barbara, Biology II Building, University of California, Santa Barbara, CA 93106-9610, […]

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Peptide bioregulators: A new class of geroprotectors (excerpt)

Abstract This paper reviews the results of long-term studies by the authors on the clinical efficacy of peptide bioregulators (Timalin, Thymogen, Vilon, Epithalamin, Prostatilen, Cortexin, and Retinalamin) for the prevention of diseases and treatment of people of all ages. Particular […]

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Efficacy of Cortexin in acute and recovery periodes of hemispheric ischemic stroke

Abstract in English, Russian AIM: To study the effectiveness and sustained effects of early appointment of a repeated course of low-dose drug cortexin neuroprotection in patients in acute and recovery period of hemispheric ischemic stroke. MATERIAL AND METHODS: The study […]

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Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth

In studies intended to improve healing of transected Achilles tendon, effective was a stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419). Currently in clinical trials for inflammatory bowel disease (PLD-116, PL 14736, Pliva), it ameliorates internal and external wound healing. […]

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