The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Highlights MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis MOTS-c protects against age- and diet-dependent insulin resistance and obesity […]

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Humanin and age-related diseases: a new link?

Front. Endocrinol., 04 December 2014 | https://doi.org/10.3389/fendo.2014.00210 Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery over a decade ago, a role for HN has been reported in many biological processes such as apoptosis, cell survival, substrate metabolism, inflammatory […]

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Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

The Wnt/β-catenin pathway has been implicated in hair follicle development and hair regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway involved in hair regrowth and wound-induced hair follicle neogenesis via an interaction with Dishevelled. CXXC5 was upregulated […]

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Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

Abstract The innate immune system utilizes many approaches for defense against invading microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil extracellular traps (NETs) and release of antimicrobial peptides (AMPs). While classically thought to be driven by adaptive immunity, the development […]

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