The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Highlights MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis MOTS-c protects against age- and diet-dependent insulin resistance and obesity […]

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