Humanin 10 mg mitochondrial peptide, cell protection, cellular energy efficiency, longevity research


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Humanin 10 mg

Humanin was independently found by three different labs looking at different parameters. The first to publish, in 2001, was the Nishimoto lab, which found humanin while looking for possible proteins that could protect cells from amyloid beta, a major component of Alzheimer’s disease.[3] The Reed lab found humanin when screening for proteins that could interact with Bcl-2-associated X protein (Bax), a major protein involved in apoptosis.[7] The Pinchas Cohen lab independently discovered humanin when screening for proteins that interact with IGFBP3.[12]

Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Molecular Formula: C119H204N34O32S2
Molecular Weight: 2687.3 g/mol
PubChem SID: 16131438
CAS Number: 330936-69-1
Synonyms: formyl humanin, HNGF6A protein

THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. All product information available on this website is for educational purposes only.


Experiments using cultured cells have demonstrated that humanin has both neuroprotective as well as cytoprotective effects and experiments in rodents have found that it has protective effects in Alzheimer’s disease models, Huntington’s disease models and stroke models.[15]

Humanin is proposed to have myriad neuroprotective and cytoprotective effects. Both studies in cells and rodents have both found that administration of humanin or humanin derivatives increases survival and/or physiological parameters in Alzheimer’s disease models.[16][17] In addition to Alzheimer’s disease, humanin has other neuroprotective effects against models of Huntington’s diseaseprion disease, and stroke.[18][19][20] Beyond the possible neuroprotective effects, humanin protects against oxidative stress, atherosclerotic plaque formation, and heart attack.[21][22][23][24] Metabolic effects have also been demonstrated and humanin helps improve survival of pancreatic beta-cells, which may help with type 1 diabetes,[25] and increases insulin sensitivity, which may help with type 2 diabetes.[26] In rats, the humanin analog appears to normalize glucose levels and reduce diabetes symptoms.[27]

Rattin shows the same ability as humanin to defend neurons from the toxicity of beta-amyloid, the cause of degeneration in Alzheimer’s disease.[8]

Small humanin-like peptides are a group of peptides found in the mitochondrial 16S rRNA, and also possess retrograde signaling functions.

Selected literature:

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons

The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases


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