1 vial of lyophilized epitalon peptide 10 mg
Unlabeled vial for your discretion – color-coded cap for identification.
Epitalon (Epithalamin) is a peptide studied and utilized for its anti-aging effects. It has been shown to be a potent anti-oxidant, comparable to melatonin, and may confer longevity benefits.
Epitalon is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called Epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.
Khavinson first extracted Epithalamin from the pineal gland of calves, however due to the inherent limitations in production, he formulated a synthetic version of the peptide called Epitalon.
Epitalon is usually administered via intravenous or intramuscular injection or transdermally (through the skin), as peptides are broken down in the digestive tract and therefore unable to enter the bloodstream intact where they can exert their effects.
What the Research Shows
Epitalon Increases Average and Maximal Lifespan in Fruit Flies, Rats and Mice
When the peptide was administered to fruit flies during the larval stage, it was shown to increase the average lifespan by 11-16 percent[R].
In a study on rats exposed to equal amounts of light and darkness, varying amounts of light and darkness, or permanent light illumination, Epitalon increased maximal lifespan in all three groups by 68 days, 95 days, and 24 days, respectively, in comparison to controls [R].
In mice of model of hypertension, injections of Epitalon did not affect average life span of the mice, but did increase the maximal lifespan by 12.3% [R]
3) Epitalon Increases Enzyme Activities
A decrease in pancreatic enzymes has been shown to occur in elderly individuals [R]
In both young and old rats, Epitalon increased the activity of enzymes that digest protein and sugar, with the effect more pronounced in the older rats [R].
Another study found that the peptide increased enzyme activity in the small intestine of aged rats [R].
4) Epitalon Increases Melatonin Secretion and Corrects Circadian Rhythm
As we age, our circadian rhythms becomes disrupted and less pronounced, coinciding with decreased melatonin secretion and altered sleep cycles [R].
In aging monkeys, Epitalon stimulated evening melatonin secretion and reestablished the circadian rhythm of cortisol release. [R]
In 14 elderly people, epithalamin improved melatonin production and altered its cycle and peak concentrations to resemble those of young people [R].
5) Epitalon Fights Cancer
Many studies in rats and mice have shown that Epitalon strongly inhibits the development of cancer and tumors and induces cancer cell death.
When Epitalon was given to rats with colon cancer, Epitalon increased lymph flow (containing white blood cells) and apoptosis (programmed cell death), and slowed cancer growth [R].
In mice with mammary tumors, Epitalon significantly decreased the number of mice with multiple tumors and decreased the maximum size of tumors in comparison to control mice [R]. The researchers also found that the peptide reduced the expression of certain genes that, when over-expressed, play a key role in the development of breast cancer in both mice and humans.
Another study in mice found that treatment with Epitalon reduced the number of mice with malignant tumors (cancerous tumors) and prevented the cancer from metastasizing (moving to another location in the body) in all of the treated rats [R] In contrast, 3 out of the 9 mice that did not receive treatment with Epitalon saw metastases.
6) Epitalon May Treat Retinitis Pigmentosa and Improve Retinal Health
Retinitis pigmentosa is genetic, degenerative eye disease that results in the degeneration of the rods in the retina. Rods are one of two types of receptors in the eye (the other one being cones) that convert light into chemical signals that can be processed by the brain.
In a rats, Epitalon improves the function of retina cells by preserving their structure and preventing degeneration [R]. In a clinical trial, improved degenerative damage to the retina (due to retinitis pigmentosa) in 90% of the patients [R].
7) Epitalon Improves Antioxidant Status
Oxidate stress, which occurs when the body has a deficit in antioxidant to counteract the effects of free radicals (molecules that are missing electrons), has been shown to play a causative role in many diseases, including heart disease, cancer, diabetes, and even neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases [R]
One of the most potent antioxidants produced by the human body (endogenous antioxidants) is melatonin [R]
Epitalon’s antioxidant effects are thought to be in part due to its ability to stimulate melatonin production as well as mechanisms other than through the action of melatonin [R]. In male rats, epithalamin increases total antioxidant capacity by 36% and superoxide dismutase (SOD, a powerful endogenous antioxidant) by 19% [R].
When epithalamin was incubated with blood taken from breast cancer patients increased the activity of antioxidant enzymes and increasing levels of antioxidative vitamins [R]
While the preclinical studies on Epitalon look very promising, there is still a lot of research that needs to be conducted in healthy and diseased individuals.
Note: Epitalon has not been approved by the FDA.
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RESEARCH PRODUCT – NOT INDENTED FOR HUMAN CONSUMPTION.