Description
Pantocrine 50 ml deer antler extract
original & the real thing – please note that due to the war in Ukraine, this product is currently very hard to get so supplies are limited.
Deer antler velvet has been used in traditional Chinese medicine for thousands of years but has recently gained popularity in Western medicine as an ergogenic aid. According to Oriental medicine deer antler velvet can be attributed to enhancing immune system function, improving athletic performance, increasing muscle recovery, enhancing sexual function, improving disease recovery, and enhancing cardiovascular function.
Pharmacodynamics
Natural biologically active substances (amino acids, nucleotides, vitamins, minerals, phospholipids, fatty acids, sterols), which are part of the drug, are necessary for building your own enzymes, hormones, cellular and tissue structures, strengthening immune defenses.
The drug stimulates (tones) the nervous system and muscles, metabolism and basic physiological processes, promotes adaptation and resistance of the body to adverse environmental factors, increased physical and mental stress, infectious diseases.
The drug has a stimulating (tonic) effect on the nervous system and muscles, metabolism and basic physiological processes, promotes adaptation and body resistance to adverse environmental factors, increased physical and mental stress, and infectious diseases.
Indications for use
As part of a comprehensive treatment:
- Overfatigue, nervous exhaustion, neurosis, asthenic conditions caused by infectious diseases (flu, tuberculosis, etc.), low blood pressure;
- Anemia and decreased immunity, respiratory diseases, digestive and metabolic disorders (obesity);
- Sexual disorders in women (menstrual irregularities, decreased libido) and men (impotence caused by radiation, concomitant diseases and psycho-emotional stress, premature ejaculation, weak sexual activity in the elderly);
- To increase efficiency when performing heavy work, stay in harsh climatic and adverse environmental conditions.
Contraindications
Hypersensitivity to the drug, arterial hypertension, organic heart disease, angina pectoris, severe atherosclerosis, increased blood clotting, severe forms of nephritis, diarrhea, malignant neoplasms.
Interaction with other drugs and other types of interactions
Pantocrine should not be prescribed with calcium preparations, drugs that increase blood coagulation (vitamin K) and stimulate the reduction of smooth intestinal muscles (domperidone). Pantocrine enhances the effects of piracetam and other nootropic drugs.
Application
For adults, the drug should be taken orally by 20-40 drops, after dissolving them in a small amount of water, 30 minutes before meals or 2:00 after meals, 2-3 times a day. For children over the age of 7 years, the drug is used orally at the rate of 1 drop for each year of life, after having previously dissolved in a small amount of water, 30 minutes before meals or 2:00 after meals 2 times a day. The last dose is 4 hours before bedtime. The course of treatment is 3-4 weeks. As prescribed by the doctor, the course of treatment can be repeated.
Overdose
With an overdose of the drug, headache, redness of the skin, nervous agitation, diarrhea can be noted. The treatment is symptomatic.
Adverse reactions
When using the drug, headache, itching of the skin can rarely be observed. In people with hypersensitivity to the components of the drug, allergic reactions are possible.
Application features
With prolonged use in high doses, it is necessary to control blood pressure, blood coagulation and kidney function. With a pronounced side effect, the use of pantocrine should be discontinued and the question of reducing the dose or stopping the drug should be resolved. When storing the drug, precipitation is allowed, therefore, before taking it, the bottle must be shaken.
Use during pregnancy or lactation
The drug contains ethanol. There is no experience with pregnant women and women during breastfeeding.
Children
The drug contains ethanol. The drug is used for children aged 7 years.
The ability to influence the reaction rate when driving vehicles or other mechanisms
The drug contains ethanol. The effect on the ability to drive vehicles or work with mechanisms is not known.
Composition:
- active substance: extract from the antlers of maral, red deer or from the antlers of spotted deer (1: 6.58)
- excipients: flavor “Pear”, ethanol 52%.
Release form
Liquid alcoholic extract.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life is 2 years.
Antler Velvet and the Immune System
The use of antler velvet to augment the immune system has been used in traditional Chinese medicine for over 2,000 years (Dai et al., 2011)(Kuo et al., 2012)(Kang et al., 2006)(Kim et al. 2004). However, there is still little research that identifies the bioactive 6 components associated with the immunomodulatory effects. One study attempted to identify an immunomodulatory in antler velvet, suggesting this component was phosphatidylcholines. The results were not consistently reproducible due to experimental conditions, concentrations, and species of phosphatidylcholines (Kim et al. 2004). Although the bioactive component in antler velvet has not been conclusively reported, many other studies have found immunomodulatory effects with antler velvet supplementation. Staphylococcus aureus is a pathogen that can cause serious infections at the skin and soft tissue as well as the blood stream, including pneumonia or bone/joint infections. Dai et al. found the number of S. aureus pathogens in the peritoneal lavage fluid and kidney were significantly (p<.05) lower in mice treated with varying dosages of velvet antler when compared to those of control mice. In the same set of S. aureus-infected mice, ones who received pretreatment of antler velvet supplementation had significantly lower levels of inflammatory cytokines, interleukin 6 (1,000pg/ml1) and transforming growth factor beta 1 (300pg/ml1) (p<.05). This data suggests antler velvet supplementation inhibited the production of proinflammatory cytokines (Dai et al., 2011). Deer antler velvet has also been attributed to preventing allergic and asthmatic effects. Serum immunoglobulin E (IgE) is a type of antibody the immune system overproduces when an allergen is present. IgE is the most important clinical biomarker for allergic responses (Kuo et al., 2012). Supplementation with antler velvet powder was able to significantly inhibit the increase in serum level of IgE (p<.01) for allergic airway sensitized mice at 21 days (.6 unit/ml) and 28 days (1.0 unit/ml). The reduction in serum IgE is believed to relieve the allergic symptoms by mediated mast cells.
Recently many studies have focused on the use of antler velvet as a treatment for diseases, such as rheumatoid arthritis and osteoarthritis (Kang et al., 2006)(Allen et al. 2002)(Allen et al. 2008)(Moreau et al. 2004). Patients with rheumatoid arthritis often seek complimentary medications or supplements in an attempt to find symptom in relief (Allen et al. 2008). Rats with type 2 collagen-induced arthritis that received deer antler extract (43±7.2) at varying dosages had a significantly lower severity (p<.05) of arthritic scores in comparison to the placebo group (90±9.6), these severity scores were also dose-dependent (Kang et al., 2006). Allen et al. focused on whether or not elk antler velvet could be taken concurrently with a variety of traditional rheumatoid arthritis medication and results showed no significant adverse effects at dosages of 2,4 or 6 capsules of 215mg. After 6 months of supplementation there were no statistically significant differences on any outcome measures when comparing the elk velvet antler groups and placebo (Allen et al. 2008). A possible rationale for this lack of consistent statistical findings between the rat and human studies could be due to higher dosage given to rats relative to body weight. In another animal model testing the effect of antler velvet as a treatment for osteoarthritis in dogs, the intervention group received 2, 3 or 4 capsules of 280mg per day, based on overall weight (Moreau et al. 2004). A dog weighing 60-79.9kg received 1,120mg of antler velvet per day, which in comparison to the previous study by Allen et al. was substantially more than some human participants were consuming. Results showed that after 60 days of oral consumption vertical ground reaction force (GRF) peak and craniocaudal GRF peak significantly improved. Correspondingly, owner’s assessments of activity performance scores significantly improved pre to post-treatment and in comparison to dogs that received placebo only (Moreau et al. 2004).
Antler Velvet Improving Cardiovascular Function
Congestive heart failure is a condition in which the heart does not circulate blood in the body as efficiently as it should. In spite of the fact that there is no such term as “heart failure” in traditional Chinese medicine, deer antler velvet has been used to treat symptoms associated with heart failure for thousands of years (Shao et al., 2012). These symptoms can be classified as labored breathing, palpitation, and edema. Left coronary artery litigation is used in animal models mimic myocardial infarction and heart failure. Shao et al. investigated the therapeutic effects of antler velvet versus captopril on rats with heart failure following myocardial infarction. This study found that antler velvet and captopril failed to reverse the effects of myocardial infarction on structural parameters (p>.05). However, results did indicate that both treatments partially reversed the effect of functional damage (antler velvet-13.40±2.91, control9.11±2.62) caused by myocardial infarction. Supporting the belief that antler velvet shows comparable therapeutic effects with captopril, and could be used concurrently with medications to treat heart failure (Shao et al., 2012).
Antler Velvet and Disease Recovery
Traditionally used as a tonic, antler velvet has also been considered to possess bone strengthening properties and used in therapy for bone diseases such as avascular necrosis (Shi et al., 2010). Avascular necrosis is a disease that causes bone tissue death due to lack of blood flow to the area. In rats with corticosteroid induced avascular necrosis, treatment with antler extract for 60 days promoted osteoblast proliferation. The observation of the femoral head using transmission electron microscope showed after treatment with antler extract, the cells of the femoral head were gradually recovering at a dose-dependent rate. In rats fed 800mg/kg of antler extract, the degree of necrosis was significantly reduced (0.14±.01) (p<.05) in comparison to the model group (Shi et al., 2010). These results show that antler extract had a positive effect treating avascular necrosis by stimulating metabolism of bone cells and further promoting proliferation of osteoblasts. Although cell proliferation is beneficial for a bone disease like avascular necrosis, it would be contraindicated with a disease like cancer. Fraser et al. focused on whether or not orally consumed deer antler velvet would promote colon cancer growth. Colon cancer was selected because it is a common type of cancer in Western countries with men and women evenly affected. Since deer antler velvet is generally consumed orally, it could potentially result in the release of various angiogenic factors across the gut leading to enhanced growth of cancerous tumors. Upon autopsy of colon cancer induced rats, results showed that when comparing the control and antler velvet treatment there was no statistically significant difference in volume of tumors (Fraser et al., 2010). Therefore, deer antler velvet did not stimulate the proliferation or metastasis of cancerous cells in the colon. Results showed that rats treated with deer antler velvet had a greater portion of lower grade colon tumors (p<.03) and for total tumors (p<.0001) compared with control rats (Fraser et al., 2010). These findings are important because they suggest deer antler velvet decreased the severity of pathologies, when previously it was believed that treatment would result with in an increase in severity.
Antler Velvet and Sexual Function
Late-onset hypogonadism (LOH) is associated with advancing age characterized by hypogonadal symptoms and low testosterone levels (Zang et al., 2015). In recent years, testosterone replacement therapy has been used to relieve symptoms in men with LOH (Zang et 10 al., 2015). Despite its recurrent use, testosterone replacement has side effects that cannot be ignored, often times leaving men with LOH searching for an alternative treatment. The reputation for improving sexual energy has resulted in antler velvet being used as an aphrodisiac (Conaglen et al. 2003). Zang et al. focused on whether the consumption of antler velvet could enhance the level of testosterone and improve sexual function in aging male mice. Mice were separated into three groups treated at different antler velvet dosages of 100, 200, or 300mg/kg a day, there was also a placebo group. At a dose of 200mg/kg, testosterone level (9ng/ml-1 ) increased significantly (p<.05) in comparison to the placebo group, as well as the frequency of mount (p<.05) (Zang et al., 2015). Significant differences were not found with the two other dosage groups. These results show that the administration of antler velvet could improve sexual function as a byproduct of increasing testosterone level. In a similar study focusing on deer antler velvet and sexual function in aging men Conaglen et al. found no significant differences in hormone levels after supplementation with antler velvet. After 12 weeks of supplementation with deer antler velvet at 1,000mg/day there were no significant changes in free testosterone and total testosterone levels. Self-reported scores on the International Index of Erectile Dysfunction and overall satisfaction were lower in the deer antler velvet group than in the control group (Zang et al., 2015). The variability in response between the two studies could be a result of how the antler velvet is collected and processed. It should be understood that different batches could have varying levels of composition, concentration and content.
Antler Velvet and Cell Growth/Tissue Remodeling
Antler velvet has been attributed to containing growth factor components, which are other naturally-occurring substances that contain growth factors proven efficient in enhancing cell growth and wound repair (Mikler et al. 2004). Sunwoo et al. found that the addition of water-soluble extract significantly promoted the growth of fibroblasts (40×104 cells) in cultured bovine skin, in a dose-dependent manner supporting the presence of growth promoting components in the antler velvet. Fibroblasts are a type of cell that synthesize the extracellular matrix and collagen playing a critical role in wound healing (Sunwoo et al. 1997). To expand on this study, Mikler et al. made full-thickness wounds in rats with diabetes, and a topical placebo gel or antler velvet gel was applied immediately after and days following the incision. The antler velvet group had significantly smaller wounds at day 6 (50% of initial wound) and 7 (40% of initial wound) in comparison to the placebo (p<.05), there was also a trend towards decreased inflammation in the antler treatment group at 2 days’ post-incision. These results indicate that antler velvet may accelerate second intention wound healing in patients with diabetes (Mikler et al. 2004).
Antler Velvet and Performance Enhancement
Antler velvet is most commonly used as a performance-enhancing supplement, with proposed benefits on fatigue resistance, muscular endurance, muscular strength, and aerobic performance. The research into these effects has increased in recent years but results have been controversial. Broeder et al. found that after supplementation with New Zealand deer antler velvet the 1-RM values increased significantly both in absolute and relative terms to total body weight. There was also a significant improvement in aerobic capacity by 9.8% from pre to post treatment period (p=.002)(Gilbey & Perezgonzalez, 2012)(Broeder et al., 2004). Sleivert et al. used 6-RM and isokinetic knee extensor strength as a measurement of muscular strength and found no statistical difference between the placebo group and antler velvet intervention group for 6-RM. Yet, there was a statistically significant difference found for isokinetic knee extensor strength between the two groups (30±21% vs. 13±15%, p=.04). Dissimilar to findings by Broeder et al. there was no endocrine, red blood cell mass or VO2max changes in either group (Sleivert et al., 2003) (Gilbey & Perezgonzalez, 2012). These varying results in muscular strength and aerobic capacity could be a result of substantial difference in antler velvet dosage between the two studies, with Sleivert using 1500mg/day and Broeder using 1350mg/day. In another study that dosed 1350mg/2xday, participants who were given the intervention significantly increased their VO2max score pre to post (9.8%) (p<.05) (Earnest et al., 2015). However, in this same study there were no changes in anaerobic power, muscular strength or hematologic variables (Earnest et al., 2015). To determine the anti-fatiguing factor attributed to deer antler velvet supplementation, the swimming capacity of mice was studied using a forced swimming test. During the test mice were judged to be fatigued when they failed to rise to the water’s surface within 8 seconds (Chen et al. 2012). After antler velvet administration the swimming time (22 min vs. 16 min) increased significantly when compared to the control group (p<.05) (Chen et al. 2012)(Jang et al., 2014). Mice were being dosed antler velvet at equivalent to human dosages. There were no significant differences in blood glucose or lactate levels between the groups’ post forced swimming test (Jang et al., 2014). Results also indicated slight reductions in fatigue-related blood biochemical parameters (BUN and LA), but never reached statistical significance (Chen et al. 2012). The reasoning as to how antler velvet decreases fatigue is not conclusive, it could 13 be a result of decreasing biochemical parameters or upregulating the genes associated with muscle strength (Chen et al. 2012). Syrotuik et al. focused on the effect of antler velvet supplementation on rowers, specifically looking at resting and exercise-stimulated hormones in men and women. Rowing being a predominately muscular endurance sport could, in theory, benefit from the anti-fatiguing effect of antler velvet. The main findings indicated that 560mg of antler velvet did not alter any measured hormonal or physiologic response (serum growth hormone, serum cortisol) when compared to the placebo group. This lack of any significant findings could be due to the fact that mice usually receive higher dosages than human participants, the exact dosage needed to elicit a response is not known and could be a major limitation to these studies (Syrotuik et al. 2005)
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