AAPE human adipose-derived stem cell conditioned medium for hair restoration

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Description

AAPE (Advanced Adipose-derived stem cell Protein Extracts) for Hair Restoration
LIMITED QUANTITY AVAILABLE 
We are happy to bring you a novel, state-of-the-air hair restoration treatment with outstanding properties and clinical evidence. 
One kit contains 6 vials with solvent/activator – a half year treatment course.AAPE® is a mixture of refined growth factors extracted from human adipose that promotes hair growth and scalp health with outstanding ingredients. It is composed of approximately 150 various kinds of human body-friendly proteins like:

  • type 1 collagen, fibronectin
  • TGF beta-1
  • bFGF
  • VEGF, PDGF, KGF, HGF

AAPE® increases proliferation of dermal papilla cells of human hair follicle. Dermal papilla cells consist of a discrete population of specialized fibroblasts important in morphogenesis of hair follicle and control of hair growth cycle. It turns over dying skin cells twice faster than normal skin. AAPE is a mixture of refined growth factors extracted from human adipose-derived stem cells conditioned media and induces proliferation of dermal papilla cells of human hair follicles to make hair regrow.

Active proteins are derived from human source and do not have allergic reactions → no skin irritation.

Each growth factor has pharmacological effect but combination of growth factors may enhance the pharmacological action of single protein.

Apply with dermaroller, mesotherapy, electroporation, RF devices or laser.

AAPE® is the first product based on stem cell described in SCI journals with clinical results in humans.

  •  US FDA, CFDA approval
  •  PCPC US registration
  •  More than 20 papers in SCI journals
  •  28 patents registered worldwide

 

 

 

 

Mechanism

What stage of hair loss AAPE can help?


Before/after

Protocol

AAPE can be applied with various types of treatments such as micro-needle, fractional laser, and iontophoresis. They help the penetration of active ingredients of AAPE into skin to the maximum.

Treatment video:

 

Clinical literature:

  • Exosomes from human adipose derived stem cells promote proliferation and migration of skin fibroblasts
    Kim, S., Choi, E. W., Seo, M. K., Woo, E. Y., Kim, S. H., Park, E. J.
    2017 Experimental Dermatology
  • The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors
    Won CH, Park CH, Xuwei Wu, Thanh-Nga Tran, Park KY, Park BS, Kim DY, Kwon OS, Kim KH
    2017 Current Stem Cell Research and Therapy
  • Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells
    Hirotaro Fubuoka, keigo Narita, Hirotaka Suga 2017
    Current Stem Cell Research and Therapy
  • Up-to-date Clinical Trials of Hair Regeneration using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss
    Shin HS, Ryu HH, Kwon OS, Park BS, Jo SJ 2017 Current Stem Cell Research and Therapy
  • Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study
    Shin HS, Ryu HH, Kwon OS, Park BS, Jo SJ 2015 International Journal of Dermatology
  • AAPE proliposomes for topical atopic dermatitis treatment
    Alexander Jahn, Song CK, Prabagar Balakrishnan, Hong SS, Lee JH, Chung SJ, Kim DD 2014 Journal of Microencapsulation
  • Advanced adipose-derived stem cell protein extracts with anti oxidant activity modulates matrix metalloproteinases in human dermal fibroblasts
    Chae, Y.B., Lee, J.S., Park, H.J., Park, I.H., Kim, M.M., Park, Y.H., Kim, D.S., Lee, J.H., 2012
    Environmental Toxicology and Pharmacology
  • The Effect of Secretory Factors of Adipose-Derived Stem Cells on Human keratinocytes
    Moon KM, Park YH, Lee JS, Chae YB, Kim MM, Kim DS, Kim BW, Nam SW, Lee JH 2012
    International Journal of Molecular Sciences
  • Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: Evidence of increased growth factor secretion
    Park, B.-S., Kim, W.-S., Choi, J.-S., Kim, H.-K., Won, J.-H., Ohkubo, F., Fukuoka, H. 2010 Biomedical Research
  • Hair growth-promoting effects of adipose tissue-derived stem cells
    Won, C.H., Yoo, H.G., Kwon, O.S., Sung, M.Y., Kang, Y.J., Chung, J.H., Park, B.S., Sung, J.-H., Kim, W.S., Kim, K.H.
    2010 Journal of Dermatological Science
  • Adipose-derived stem cells and their secretory Factors for Skin Aging
    Park, B.-S., Jang, K.A., Sung, J.-H., Park, J.-S., Kwon, Y.H., Kim, K.J., Kim, W.-S. 2010
    Textbook of Aging Skin
  • The wound-healing and antioxidant effects of adipose-derived stem cells
    Kim, W.-S., Park, B.-S., Sung, J.-H 2009
    Expert Opinion on Biological Therapy
  • Protective role of adipose-derived stem cells and their soluble factors in photoaging
    Kim, W.-S., Park, B.-S., Sung, J.-H. 2009
    Archives of Dermatological Research
  • Hypoxia-enhanced wound-healing function of adipose-derived stem cells: Increase in stem cell proliferation and up-regulation of VEGF and bFGF
    Lee, E.Y., Xia, Y., Kim, W.-S., Kim, M.H., Kim, T.H., Kim, K.J., Park, B.-S., Sung, J.-H.
    2009 Wound Repair and Regeneration
  • Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors
    Kim, W.-S., Park, B.-S., Park, S.-H., Kim, H.-K., Sung, J.-H.
    2009 Journal of Dermatological Science
  • Whitening effect of adipose-derived stem cells: A critical role of TGF-β1
    Kim, W.-S., Park, S.-H., Ahn, S.-J., Kim, H.-K., Park, J.-S., Lee, G.-Y., Kim, K.-J., Whang, K.-K., Kang, S.-H., Park, B.-S., Sung, J.-H. 2008
    Biological and Pharmaceutical Bulletin
  • Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging
    Park, B.-S., Jang, K.A., Sung, J.-H., Park, J.-S., Kwon, Y.H., Kim, K.J., Kim, W.-S.
    2008 Dermatologic Surgery
  • Wound healing effect of adipose-derived stem cells: A critical role of secretory factors on human dermal fibroblasts
    Kim, W.-S., Park, B.-S., Sung, J.-H., Yang, J.-M., Park, S.-B., Kwak, S.-J., Park, J.-S.
    2007 Journal of Dermatological Science
  • Evidence supporting antioxidant action of adipose-derived stem cells: Protection of human dermal fibroblasts from oxidative stress
    Kim, W.-S., Park, B.-S., Kim, H.-K., Park, J.-S., Kim, K.-J., Choi, J.-S., Chung, S.-J., Kim, D.-D., Sung, J.-H.
    2007
    Journal of Dermatological Science
  • A novel secretory vesicle from Deer Antlerogenic Mesenchymal Stem Cells- Conditioned Media (DaMSCs-CM) promotes tissue regeneration
    Seo MK, Kim JC, Kim HK, Choi EW, Jeong SY, Nam KC, Jang MH 2018 Stem Cells International
  • Stemness-attenuating miR-503-3p as a paracrine factor regulates cancer stem cell growth
    Seo MS, Kim SM, Won EY, Park EJ, Ko SY, Choi EW, Jeong HJ, Jang MH
    2018 Stem Cells International
  • Efficacy and Safety of Autologous Stromal Vascular Fraction in the Treatment of Empty Nose Syndrome
    Kim DY, Hong HR, Choi EW, Yoon SW, Jang YJ
    2018 Clinical and experimental otorhinolaryngology
  • Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease
    Seo MK, Park EJ, Choi EW, Kim S 2018
    Journal of Dairy Science
  • Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting
    Kim, S. M., Yang, Y. S., Oh, S. J, Hong, Y. S., Seo, M. K., Jang, M. H.
    2017 ELSEVIER
  • Novel porous matrix of hyaluronic acid for the three-dimensional culture of chondrocytes
    Kang JY, Chung CW, Sung JH, Park BS, Choi JY, Lee SJ, Choi BC, Shim CK, Chung SJ, Kim DD
    2009 International Journal of Pharmaceutics

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