PINEAMIN PPG (Polypeptides of Pineal Gland)


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Pineamin® Polypeptides of Pineal Gland


PINEAMIN® is the first injectable drug with an innovative PPG (Polypeptides of Pineal Gland) class-effect and anti-age effect. It is prescribed for women during the period of age-related changes, when symptoms such as hot flashes, sweating, insomnia, depression, irritability and other manifestations of menopause appear.

Pineamin is an innovative biotechnological drug that combines proven efficacy and safety.

It is based on the latest scientific developments in the field of neuroendocrinology and gynecology: the drug contains PPG-peptides, which, indirectly through the activation of internal inhibitory structures, can solve the problem of menopause symptoms without resorting to synthetic substitutes or analogs of female hormones. This mechanism of action is fundamentally different from the solutions of traditionally used therapy – this is the unique innovative PPG class-effect of the drug.

Pineamin is applied in a short course of 10 days in the form of intramuscular injections. The positive effect of using Pineamin is confirmed by research, it lasts up to 180 days.

The mechanism of action and route of administration of Pineamine provides a high safety profile, and almost complete absence of side effects.

The traditional method of dealing with the manifestations of menopause is hormonal therapy. However, despite its effectiveness, a large number of patients do not agree to treatment due to a serious number of restrictions, contraindications and side effects.

Centrally acting drugs, in particular Pineamin®, can be prescribed in situations where hormonal therapy has limitations or contraindications, or the patient refuses to take hormonal drugs.


  • Proven effectiveness – proven in a multicenter, double-blind, placebo-controlled, randomized trial.
  • High profile of tolerance and safety – safe for a 10-day course, does not cause serious adverse events.
  • Lack of contraindications – no restrictions and contraindications inherent in traditional therapy.
  • Convenient course of treatment – 2-3 courses per year. The effect of one course of injections lasts up to 180 days.
  • Supporting anti-age effect – active effect on age-related skin changes.

When taken, the drug optimizes the epiphyseal-hypothalamic relationship, normalizes the function of the anterior pituitary gland and the balance of gonadotropic hormones.

In a double-blind, placebo-controlled study of the drug in a population of postmenopausal women, it was found that when using it, a significant decrease in the severity of climacteric disorders according to the Kupperman index occurs due to the positive effect of the drug on the neurovegetative manifestations of menopause.
Earlier, in preclinical studies on experimental animals with long-term (30 and 90 days) intramuscular administration of the drug Pineamin did not reveal its negative effects on the main systems (nervous, cardiovascular, hematopoietic, urinary and respiratory), as well as on metabolism and general condition organism.


  • Neurovegetative disorders in climacteric syndrome in women with contraindications to hormone replacement therapy (HRT) or refusal to carry it out.
  • Improvement of psycho-emotional and general physical condition.
  • Contributes to the normalization of the melatonin-forming function of the pineal gland.
  • Stimulates the melatonin-forming function of the pineal gland in the elderly.

The drug PINEAMIN®, a lyophilisate for the preparation of a solution for intramuscular administration of 10 mg, is a complex of water-soluble polypeptide fractions of the pineal gland (pineal gland) of young animals not older than 12 months of age, isolated from a dry Pineamine extract (GEROPHARM LLC, Russia) containing glycine as a stabilizer (Ajinomoto Co. Inc., Japan; Panreac, Spain) in a 1: 2 ratio.

The drug is administered intramuscularly.

Before injection, the contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution and injected once daily at a dose of 10 mg for 10 days.
If necessary, repeat the course in 3-6 months.
If the injection is missed, it is not recommended to enter a double dose, but to carry out the next injection as usual on the scheduled day.

Form release:
Lyophilisate for preparation of solution for intramuscular and parabulbar injections 10 vials of 10mg


Guaranteed authenticity and quality:
100% Original from GEROPHARM (Russian Federation)

Development and production:
GEROPHARM (Russian Federation)

St. Petersburg Institute of Bioregulation and Gerontology


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