Memantine hcl 10 mg (Merixino, Maruxa) dementia, Alzheimer’s, neuroprotection


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Memantine 10 mg x 56 tabs

Memantine is a moderate-affinity glutamate antagonist that primarily takes action at the N-methyl-D-aspartate receptor site. It has US FDA and European Medicines Agency approval for the treatment of moderate-to-severe Alzheimer’s disease. Memantine replaces Mg2+ at the N-methyl-D-aspartate receptor, blocking pathological glutamate activity but allowing normal glutamate action at this site. Consequently, calcium homeostasis is better maintained, reducing slow after hyperpolarization and preventing neuronal excitotoxicity and cell death. Clinical trials have shown that memantine is generally safe and well tolerated, and have provided evidence for its efficacy as assessed by cognitive, behavioral, functional and global measures. It has also been shown to be well tolerated and effective in the treatment of moderate-to-severe Alzheimer’s disease when patients received previous and ongoing treatment with donepezil. The tolerability and efficacy of memantine is under continued investigation in milder Alzheimer’s disease and other forms of dementia.

Reddit user log: “How memantine changed my life”

“Enter Memantine. I had taken 10/20mg doses for 2 weeks with not much success, other than a mild dissociated feeling that allowed me to be less self conscious. One night I choose to take a larger dose, 60mg, before bed. I woke up the next day feeling incredible! I felt light and buoyant. I had a strong desire to be outside in nature and feel the sun on my skin! Most of that day was spent outside in the sun, marveling at the trees dancing with wind, the birds singing to each other, the snake that just shed its skin. The rest of that day was spent staring into the mirror and pool trying to leave my body through my pupils. Pretty sure I came close a few times.

This was what I call my “rebirth”. I had a epiphany that day. I am strange and different, I might never fit in, but that is ok. Those so called weaknesses are also my strengths. I accepted myself as I am for the first time.

The next day I slinked around the house ( you’ll know what I mean if you’ve ever taken a high dosage of Memantine) and started to research memantine’s action of mechanism. By stopping Glutamate from binding to the NMDA receptor and thus stopping excessive amounts of calcium to flow through the channel, which was causing excitotoxicity. This exitotoxicity was apparently effecting my mood as well as cognitive function, because now I felt I could think clearer, my memory started to improve, my verbal fluency went up as well. Not only that but now I wanted to re-establish those relationships I had let go of, and create new friendships.

My energy level shot way up too. Now I work out 5 days a week at a Crossfit like gym. I also rediscovered my love for yoga after taking a decade off from practice; started taking all these different yoga classes, to see what resonated with me, 4-5 days a week. Now I am starting to get serious about a career, possibly Massage Therapy. I reconnected with my Father the other day, after not speaking for 15 years. Now I want to have a romantic relationship and eventually a family of my own, before this I had no desire for that. Everyday actions, repetitive movements, holding conversation, things people take for granted but we’re always challenging for me, started to become effortless.

Now I’m starting to feel that anything I work towards can be accomplished. Where before, no matter how hard I tried, how much I practiced, I could not get past mediocrity . Consistency was ever illusive.

This is most likely the closest I will get to my “Limitless” substance. But who knows, breakthroughs in science are happening every day.Is my life perfect now? Do I have 1000 friends fighting for my attention? Is everything effortless now? Do I have my dream job yet? Will memantine work for everybody? No.

I have to work for those things, everyday. But now I feel I can fight for myself. I can take care of myself. I’m not hopeless anymore, I’m hopeful.

Memantine has given me that chance.

ps The dosing is very tricky. I am not even close to understanding it yet. It was only after the large dose that I started to understand how it could help me. Since that day I have taken at least 20-40mg a day. But just the other day I had this strange experience. I started to feel like my old self; scared, self conscious, and tired. I went to a yoga class despite the way I was feeling. Usually I will go up to the teacher, give her a hug and make my presence known. That day I tried to blend in with all the people I didnt know. I just wanted to make it through the practice.

And I did. I started to feel a bit better too. But I left on my own without really talking to anyone. When I got home I decided to take a large dose of Memantine; about 70mg.

Soon after I started to feel more connected; to myself and others. Lying in bed that night I had a psychadelic self healing experience where all the lessons I have been learning, all the new friends I have made, started coming back to me, and resonating on a deep level.

I also saw myself from 3rd person perspective and what I saw was really beautiful and inspiring. I’ve come such a long way.

The next day I went to 7am workout, but didn’t take any Memantine. That connected feeling is still with me two days later, even though I havent taken memantine since that night.

My psychiatrist told me he couldn’t see me anymore because I was taking more than he prescribed. “I don’t need him anyway” , I though to myself.

Now Im started to think I do need someone supervising this journey. Just not him. There has got to be someone out there that is specializing and researching this substance.”

Selected literature:

The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion

Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo


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