Humanin and age-related diseases: a new link?

Front. Endocrinol., 04 December 2014 | https://doi.org/10.3389/fendo.2014.00210 Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery over a decade ago, a role for HN has been reported in many biological processes such as apoptosis, cell survival, substrate metabolism, inflammatory […]

Continue Reading

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

The Wnt/β-catenin pathway has been implicated in hair follicle development and hair regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway involved in hair regrowth and wound-induced hair follicle neogenesis via an interaction with Dishevelled. CXXC5 was upregulated […]

Continue Reading

Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro

Abstract Cortexolone 17α-propionate (clascoterone) is a novel androgen antagonist that is currently being analyzed in a large phase 2 clinical trial for the topical treatment of androgenetic alopecia (AGA). While the pathogenesis of AGA is still debated, the consensus is […]

Continue Reading

Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

Abstract The innate immune system utilizes many approaches for defense against invading microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil extracellular traps (NETs) and release of antimicrobial peptides (AMPs). While classically thought to be driven by adaptive immunity, the development […]

Continue Reading

Peptide dilution calculator

Peptide Calculator – Reconstituting Research Peptides Peptide Calculator – Reconstituting Research Peptides The Peptide Calculator measures reconstitution and peptide dosage for research. Double check peptide calculator math with 1/3ml, 50cc and 100 unit syringes. Microgram (mcg) peptide measurements are used […]

Continue Reading

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

Highlights Exercise increases circulating levels of the lipokine 12,13-diHOME in humans and mice iBAT is the tissue source for the exercise-stimulated increase in 12,13-diHOME in mice 12,13-diHOME increases fatty acid uptake and oxidation in skeletal muscle of mice Summary Circulating […]

Continue Reading

Effects of enzymatically modified isoquercitrin (EMIQ) in supplementary protein powder on athlete body

Journal of the International Society of Sports Nutrition volume 16, Article number: 39 (2019) Abstract Background Enzymatically modified isoquercitrin (EMIQ), a water-soluble quercetin, has been shown to intensify muscle hypertrophy in mice. We investigated the effect of EMIQ in supplementary protein powder on athlete […]

Continue Reading

Preclinical and Clinical Effects of Mistletoe against Breast Cancer

Abstract Breast cancer is among the most frequent types of cancer in women worldwide. Current conventional treatment options are accompanied by side effects. Mistletoe is amongst the important herbal medicines traditionally used as complementary remedies. An increasing number of studies […]

Continue Reading

Treatment of hepatitis C virus infection with human ezrin peptide one (HEP1) in HIV infected patients

Abstract This report shows the therapeutic benefit of HEP1 (human ezrin peptide 324-337; TEKKRRETVEREKE) monotherapy of hepatitis C virus (HCV) infection in HIV infected patients in two clinical studies. In the Pilot Study I, 16 of 18 patients responded well […]

Continue Reading