iRGD is a tumor penetrating peptide to fight cancer

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Author information Vascular Mapping Laboratory, Center for Nanomedicine, Sanford-Burnham Medical Research Institute at University of California at Santa Barbara, Biology II Building, University of California, Santa Barbara, CA 93106-9610, […]

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The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Highlights MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis MOTS-c protects against age- and diet-dependent insulin resistance and obesity […]

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Optimizing Platelet-Rich Plasma Gel Formation by Varying Time and Gravitational Forces During Centrifugation

Despite the increasing clinical use of topical platelet-rich plasma (PRP) to enhance tissue healing and regeneration, there is no properly standardized method of autologous PRP gel preparation. This study examined the effect of the centrifugation time and gravitational force (g) […]

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The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women

Abstract OBJECTIVE: The biological role of the adrenal sex steroid precursors–DHEA and DHEA sulphate (DS) and their decline with ageing remains undefined. We observed previously that administration of a 50 daily dose of DHEA for 3 months to age-advanced men […]

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Lactic acid and exercise to boost testosterone secretion: evidence for the involvement of a cAMP-mediated mechanism

Lactic acid and exercise to boost testosterone secretion: evidence for the involvement of a cAMP-mediated mechanism
Administration of lactate or hCG increased in a dose dependent manner testicular cyclic adenosine 3′:5′ monophosphate (cAMP) and testosterone release. Plasma testosterone increased after swimming and lactate infusion.

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