PMID: 34587244 DOI: 10.1093/jn/nxab309 Free article Abstract Cellular increases in oxidative stress (OxS) and decline in mitochondrial function are identified as key defects in aging, but underlying mechanisms are poorly understood and interventions are...
Abstract Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have...
Int. J. Mol. Sci. 2023, 24(3), 2959; https://doi.org/10.3390/ijms24032959 Abstract The molecule NAD+ is a coenzyme for enzymes catalyzing cellular redox reactions in several metabolic pathways, encompassing glycolysis, TCA cycle, and oxidative phosphorylation, and is...
Aging (Albany NY). 2023 Jan 31; 15(2): 421–440. Published online 2023 Jan 11. doi: 10.18632/aging.204476 Abstract Lithium is a nutritional trace element that is also used pharmacologically for the management of bipolar and related psychiatric disorders. Recent...
https://doi.org/10.1016/j.cmet.2020.04.008 Highlights • Mitochondrial myopathy patients have NAD+ deficiency in muscle and blood• Niacin is an efficient NAD+ booster in humans• Niacin improves muscle strength and fatty liver in mitochondrial myopathy• Niacin...
