Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

Abstract The innate immune system utilizes many approaches for defense against invading microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil extracellular traps (NETs) and release of antimicrobial peptides (AMPs). While classically thought to be driven by adaptive immunity, the development […]

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Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men

Abstract STUDY QUESTION: How potently does the novel hypothalamic stimulator of reproduction, kisspeptin, increase gonadotrophin secretion when compared with GnRH in healthy men? SUMMARY ANSWER: At the doses tested, intravenous administration of either of two major kisspeptin isoforms, kisspeptin-10 and […]

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iRGD is a tumor penetrating peptide to fight cancer

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Author information Vascular Mapping Laboratory, Center for Nanomedicine, Sanford-Burnham Medical Research Institute at University of California at Santa Barbara, Biology II Building, University of California, Santa Barbara, CA 93106-9610, […]

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The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Highlights MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis MOTS-c protects against age- and diet-dependent insulin resistance and obesity […]

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