Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

Cardiorenal Med 2020;10:42–50 https://doi.org/10.1159/000503224 Abstract Introduction: Vascular calcification (VC) is a complex, regulated process involved in many disease entities. So far, there are no treatments to reverse it. Exploring novel strategies to prevent VC is important and necessary for VC-related disease […]

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Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

Abstract NAD+ is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in patients with degenerative disorders and whether NAD+ repletion improves their symptoms has remained open. Here, we […]

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The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

https://doi.org/10.18632/aging.103534 Copyright © 2020 Yen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source […]

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Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

Abstract Background Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues. This trial aims to contribute to the establishment of effective approaches to promote […]

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Photobiomodulation for the management of alopecia: mechanisms of action, patient selection and perspectives

Clin Cosmet Investig Dermatol. 2019; 12: 669–678. Published online 2019 Sep 6. doi: 10.2147/CCID.S184979 PMCID: PMC6737896 PMID: 31686888 Abstract Photobiomodulation (PBM) or low-level laser therapy was discovered over 50 years ago, when Mester in Hungary observed regrowth of hair in mice when irradiated with a […]

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Locally acting ACE-083 increases muscle volume in healthy volunteers

Abstract Introduction: ACE-083 is a locally acting follistatin-based therapeutic that binds myostatin and other muscle regulators and has been shown to increase muscle mass and force in neuromuscular disease mouse models. This first-in-human study examined these effects. Methods: In this phase 1, […]

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A Reappraisal of Thymosin Alpha1 in Cancer Therapy

Claudio Costantini1*, Marina M. Bellet1, Marilena Pariano1, Giorgia Renga1, Claudia Stincardini1, Allan L. Goldstein2, Enrico Garaci3 and Luigina Romani1* 1Department of Experimental Medicine, University of Perugia, Perugia, Italy 2Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, United States […]

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A Plausible “Penny” Costing Effective Treatment for Corona Virus: Ozone Therapy

by Robert Jay Rowen, MD1,* and Howard Robins, DPM2 1Private Medical Practice, 2200 County Center Dr. Ste C, Santa Rosa, California, 95403, USA 2Private Medical Practice, 200 West 57th Street 203, New York, NY 10019, USA Abstract Many viruses require reduced […]

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