Platelet-rich fibrin (PRF) treatment in periodontal disease

Abstract Platelets can play a crucial role in periodontal regeneration as they are reservoirs of growth factors and cytokines which are the key factors for regeneration of the bone and maturation of the soft tissue. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous platelet concentrates prepared from patient’s […]

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The Effects of Platelet-Derived Growth Factor-BB on Human Dental Pulp Stem Cells Mediated Dentin-Pulp Complex Regeneration

Abstract Dentin‐pulp complex regeneration is a promising alternative treatment for the irreversible pulpitis caused by tooth trauma or dental caries. This process mainly relies on the recruitment of endogenous or the transplanted dental pulp stem cells (DPSCs) to guide dentin‐pulp […]

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Platelet-derived growth factors and their receptors: structural and functional perspectives

Abstract The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important functions in the development of connective tissue cells. Recent structural studies have revealed […]

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PDGF-B Gene Therapy Accelerates Bone Engineering and Oral Implant Osseointegration

Abstract Platelet-derived growth factor-BB (PDGF-BB) stimulates repair of healing-impaired chronic wounds such as diabetic ulcers and periodontal lesions. However, limitations in predictability of tissue regeneration occur due in part to transient growth factor bioavailability in vivo. Here, we report that gene […]

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Cibinetide in Inflammatory and Autoimmune Diseases: Increasing Evidence for Immune Modulation and Pleiotropic Benefit

Cibinetide, the lead compound of Araim Pharmaceuticals, Inc., a clinical stage biotechnology company pioneering the development of innate repair receptor (IRR) activator platform technology, has recently been shown to have a profound immune cell modulation, anti-inflammatory, and disease modifying activity in animal […]

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ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes

Abstract Although erythropoietin ameliorates experimental type 2 diabetes with neuropathy, serious side effects limit its potential clinical use. ARA 290, a nonhematopoietic peptide designed from the structure of erythropoietin, interacts selectively with the innate repair receptor that mediates tissue protection. […]

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New compound WAY-316606, targets a protein which is known to halt hair growth

Baldness could be treated with drug originally designed to tackle brittle bones, scientists say Osteoporosis drug has side-effect of unwanted hair growth and caused follicles to reawaken in laboratory tests Baldness could be tackled with an experimental drug that was first […]

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A Novel Function for Kojic Acid, a Secondary Metabolite from Aspergillus Fungi, as Antileishmanial Agent

Abstract Kojic acid (KA) is a fungal metabolite used as a topical treatment skin-whitening cosmetic agent for melasma in humans; however its potential as an anti-leishmanial agent is unknown. Chemotherapy is one of the most effective treatments for Leishmaniasis. However, […]

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