G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

Yool Lee, Nicholas F. Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M. Field, Amita Sehgal  Published: April 30, 2019 https://doi.org/10.1371/journal.pbio.3000228 Abstract Circadian disruption has multiple pathological consequences, but the underlying mechanisms are largely unknown. To address such mechanisms, we subjected transformed […]

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Application of ozone in the treatment of periodontal disease

Abstract Gingivitis and periodontitis are most common inflammatory diseases of supporting tissues of teeth. Role of microbial etiology and host response in progression of gingival and periodontal diseases has been well established. Because of the beneficial biological effects of ozone, […]

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Evolus ‘frown line’ treatment Jeuveau could threaten Botox revenues

Evolus’ Jeuveau (DWP-450) (prabotulinumtoxinA) will likely prove to be a strong competitor to Allergan’s Botox (botulinum toxin type A) for severe glabellar (frown) lines, with an analyst-predicted 20%–30% price reduction. However, the predicted price reduction is not huge and patients may not switch to […]

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Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster

Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To […]

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Improvement of Hair Graying during a Treatment of Male Pattern Hair Loss Using 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide Injections

Yoon Jin Choi1, Suhyun Cho1, Young Koo Kim2, and Dae Suk Kim3 1Yonsei BB Skin Clinic, Seoul, Korea, 2Yonsei Star Skin & Laser Clinic, Seoul, Korea, 3Yonsei Young Skin Clinic, Seoul, Korea Abstract Hair graying is a common age-related hair change with […]

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Efficacy and Safety of Human Placental Extract Solution on Fatigue: A Double-Blind, Randomized, Placebo-Controlled Study

Kang-Kon Lee,1 Whan-Seok Choi,1,2 Keun-Sang Yum,1 Sang-Wook Song,1 Sun-Myeong Ock,1 Sat-Byul Park,3 and Moon-Jong Kim4 Abstract Introduction. Fatigue is a common symptom, but only a few effective treatments are available. This study was conducted to assess the efficacy and safety of the human placental extract solution, which […]

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Bio-Path Announces Clinical Update to Interim Analysis of Phase 2 Prexigebersen Trial in Acute Myeloid Leukemia

March 06, 2019 08:00 ET | Source: Bio-Path Holdings, Inc. Interim Data Update from Phase 2 Study Demonstrates Meaningful Clinical Improvement with Excellent Patient Safety Profile Company Provides Clinical Development Plan with Pathways to Registration HOUSTON, March 06, 2019 (GLOBE NEWSWIRE) — Bio-Path […]

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Actovegin increases oxidative capacity in human skeletal muscle

Abstract Actovegin, a deproteinized haemodialysate of calf blood, is suggested to have ergogenic properties, but this potential effect has never been investigated in human skeletal muscle. To investigate this purported ergogenic effect, we measured the mitochondrial respiratory capacity in permeabilized […]

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Platelet Rich Fibrin in Periodontal Practice

International Journal of Dental Sciences and Research, 2017, Vol. 5, No. 5, 132-136   by Abdullah Almutairi Autologous platelet concentrates have become a rage in the field of regenerative medicine including numerous specialties like orthopedics, maxillofacial and cosmetic surgery, sports medicine […]

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