An epigenetic biomarker of aging for lifespan and healthspan

Morgan E. Levine 1 , Ake T. Lu 1 , Austin Quach 1 , Brian H. Chen 2 ,Themistocles L. Assimes 3 , Stefania Bandinelli 4 , Lifang Hou 5 , Andrea A. Baccarelli 6 ,James D. Stewart 7 , Yun Li 8 , Eric A. Whitsel 7, 9 , James G Wilson 10 , Alex P Reiner 11 ,Abraham Aviv 12 , Kurt Lohman 12 , Yongmei Liu 14 , Luigi Ferrucci 2, * ,Steve Horvath 1, 15, * received: March 20, 2018 ; accepted: April 8, 2018 ; published: April 18, 2018 https://doi.org/10.18632/aging.101414 Copyright: Levine et al. Abstract Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic […]

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Oxytocin, Sleep, and Dreams

by Patrick McNamara Ph.D. Oxytocin may be the chemical that brings dreams to life The neurohormone oxytocin has been found to influence a range of social and affiliative behaviors (MacDonald and MacDonald, 2010). Administration of oxytocin (OT) can enhance trust, empathy and a host […]

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Fisetin is a senotherapeutic that extends health and lifespan

DOI: https://doi.org/10.1016/j.ebiom.2018.09.015 Abstract Background Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. […]

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Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome–positive leukemia

Although imatinib, a BCR-ABL tyrosine kinase inhibitor, is used to treat acute Philadelphia chromosome–positive (Ph) leukemia, it does not prevent central nervous system (CNS) relapses resulting from poor drug penetration through the blood-brain barrier. Imatinib and dasatinib (a dual-specific SRC/BCR-ABL […]

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Senescent Cells in Skin Contribute to the Formation of Age Spots, and Can be Destroyed by Radiofrequency Treatment

(article from fightaging.org) Two quite interesting findings are presented in this open access paper. Firstly, the pigmented areas of skin called age spots are in large part generated by the presence of senescent cells and their detrimental effects on mechanisms of skin pigmentation. Secondly, […]

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